Per the team, the final list of cuts has resulted in the following 53-player roster. Remember that as cuts are finalized leaguewide, there may be more roster churning ahead in the next day or two, in addition to the creation of the 2016 practice squad.
- Quarterbacks (3): Trevor Siemian, Paxton Lynch, Austin Davis
- Running backs (3): CJ Anderson, Devontae Booker, Kapri Bibbs
- Fullbacks (1): Andy Janovich
- Wide receivers: (6): Demaryius Thomas, Emmanuel Sanders, Bennie Fowler, Cody Latimer, Jordan Norwood, Jordan Taylor
- Tight ends (3): Virgil Green, Jeff Heuerman, John Phillips
- Tackles (2): Russell Okung, Donald Stephenson
- Guards (5): Max Garcia, Ty Sambrailo, Michael Schofield, Connor McGovern, Darrion Weems
- Centers (2): Matt Paradis, James Ferentz
- Nose tackles (3): Sylvester Williams, Darius Kilgo, Kyle Peko
- Defensive ends (4): Derek Wolfe, Jared Crick, Adam Gotsis, Billy Winn
- Outside linebackers (5): Von Miller, DeMarcus Ware, Shane Ray, Shaquil Barrett, Dekota Watson
- Inside linebackers (4): Brandon Marshall, Todd Davis, Zaire Anderson, Corey Nelson
- Safeties (4): TJ Ward, Darian Stewart, Justin Simmons, Will Parks
- Cornerbacks (5): Chris Harris, Jr., Aqib Talib, Bradley Roby, Kayvon Webster, Lorenzo Doss
- Kicker (1): Brandon McManus
- Punter (1): Riley Dixon
- Long snapper (1): Casey Kreiter
Reserve players:
- IR: Vance Walker, Garrett Graham
- SUS: Shiloh Keo