In addition to the placements of Derek Wolfe and TJ Ward on the suspended list, the following 20 players have been cut:
- ILB Zaire Anderson
- ILB Lamin Barrow
- RB Kapri Bibbs
- WR Isaiah Burse
- CB Tony Carter
- C Dillon Day
- NT Sione Fua
- S Josh Furman
- G Ben Gardland
- TE Marcel Jensen
- ILB Steven Johnson
- TE Dominique Jones
- WR Corbin Louks
- NT Chuka Ndulue
- CB Taurean Nixon
- OLB Gerald Rivers
- T Kyle Roberts
- T Charles Sweeton
- WR Jordan Taylor
- DE Josh Watson
Using this information, the 53 man roster should look something like this beyond the fold, arranged as an approximate depth chart:
| Pos. | 1st | 2nd | 3rd | 4th |
| Offense | ||||
| QB | Peyton Manning | Brock Osweiler | Trevor Siemian | |
| RB | CJ Anderson | Ronnie Hillman | Juwan Thompson | Montee Ball |
| FB | James Casey | |||
| WR1 | Demaryius Thomas | Cody Latimer | Jordan Norwood | |
| WR2 | Emmanuel Sanders | Andre Caldwell | Bennie Fowler | |
| TE | Owen Daniels | Virgil Green | ||
| LT | Ty Sambrailo | |||
| LG | Evan Mathis | Max Garcia | ||
| C | Matt Paradis | Gino Gradkowski | ||
| RG | Louis Vasquez | Shelley Smith | ||
| RT | Ryan Harris | Michael Schofield | ||
| Defense | ||||
| DE | Malik Jackson | Vance Walker | ||
| NT | Sylvester Williams | Darius Kilgo | ||
| DE | Antonio Smith | Kenny Anunike | ||
| OLB | Von Miller | Shane Ray | Lerentee McCray | |
| ILB | Danny Trevathan | Todd Davis | ||
| ILB | Brandon Marshall | Corey Nelson | ||
| OLB | DeMarcus Ware | Shaquil Barrett | ||
| CB1 | Chris Harris, Jr. | Bradley Roby | Curtis Marsh | |
| CB2 | Aqib Talib | Kayvon Webster | Lorenzo Doss | |
| FS | Darian Stewart | Omar Bolden | ||
| SS | David Bruton | Josh Bush | ||
| Special Teams | ||||
| K | Brandon McManus | |||
| P | Britton Colquitt | |||
| LS | Aaron Brewer | |||
IR: Ryan Clady, Jeff Heuerman, Marvin Austin, Kyle Williams
SUS: Derek Wolfe, TJ Ward