Draft
| Broncos | Colts | |||||||
| 2012 | 2-36 | Derek Wolfe | High Starter | 2012 | 1-1 | Andrew Luck | Pro Bowler | |
| 2012 | 2-57 | Brock Osweiler | Backup | 2012 | 2-34 | Coby Fleener | Starter | |
| 2012 | 3-67 | Ronnie Hillman | Backup | 2012 | 3-64 | Dwayne Allen | Starter | |
| 2012 | 4-101 | Omar Bolden | Backup | 2012 | 3-92 | T.Y. Hilton | Pro Bowler | |
| 2012 | 4-108 | Philip Blake | Bust | 2012 | 5-136 | Josh Chapman | Bust | |
| 2012 | 5-137 | Malik Jackson | High Starter | 2012 | 5-170 | Vick Ballard | Bust | |
| 2012 | 6-188 | Danny Trevathan | High Starter | 2012 | 6-206 | LaVon Brazill | Bust | |
| 2013 | 1-28 | Sylvester Williams | Starter | 2012 | 7-208 | Justin Anderson | Bust | |
| 2013 | 2-58 | Montee Ball | Bust | 2012 | 7-214 | Tim Fugger | Bust | |
| 2013 | 3-90 | Kayvon Webster | Backup | 2012 | 7-253 | Chandler Harnish | Bust | |
| 2013 | 5-146 | Quanterus Smith | Bust | 2013 | 1-24 | Bjoern Werner | Bust | |
| 2013 | 5-161 | Tavarres King | Bust | 2013 | 3-86 | Hugh Thornton | Starter | |
| 2013 | 6-173 | Vinston Painter | Bust | 2013 | 4-121 | Khaled Holmes | Backup | |
| 2013 | 7-234 | Zac Dysert | Bust | 2013 | 5-139 | Montori Hughes | Bust | |
| 2014 | 1-31 | Bradley Roby | Starter | 2013 | 6-192 | John Boyett | Bust | |
| 2014 | 2-56 | Cody Latimer | Backup | 2013 | 7-230 | Kerwynn Williams | Bust | |
| 2014 | 3-95 | Michael Schofield | Starter | 2013 | 7-254 | Justice Cunningham | Bust | |
| 2014 | 5-156 | Lamin Barrow | Bust | 2014 | 2-59 | Jack Mewhort | High Starter | |
| 2014 | 6-207 | Matt Paradis | High Starter | 2014 | 3-90 | Donte Moncrief | Starter | |
| 2014 | 7-242 | Corey Nelson | Backup | 2014 | 5-166 | Jonathan Newsome | Bust | |
| 2015 | 1-23 | Shane Ray | Starter | 2014 | 6-203 | Andrew Jackson | Bust | |
| 2015 | 2-59 | Ty Sambrailo | Backup | 2014 | 7-232 | Ulrick John | Bust | |
| 2015 | 3-92 | Jeff Heuerman | Backup | 2015 | 1-29 | Phillip Dorsett | Backup | |
| 2015 | 4-133 | Max Garcia | Starter | 2015 | 3-65 | D’Joun Smith | Bust | |
| 2015 | 5-164 | Lorenzo Doss | Backup | 2015 | 3-93 | Henry Anderson | Backup | |
| 2015 | 6-203 | Darius Kilgo | Bust | 2015 | 4-109 | Clayton Geathers | Backup | |
| 2015 | 7-250 | Trevor Siemian | Starter | 2015 | 5-151 | David Parry | Starter | |
| 2015 | 7-251 | Taurean Nixon | Backup | 2015 | 6-205 | Josh Robinson | Bust | |
| 2015 | 7-252 | Josh Furman | Bust | 2015 | 6-207 | Amarlo Herrera | Bust | |
| 2016 | 1-26 | Paxton Lynch | Backup | 2015 | 7-255 | Denzell Goode | Backup | |
| 2016 | 2-63 | Adam Gotsis | Backup | 2016 | 1-18 | Ryan Kelly | Starter | |
| 2016 | 3-98 | Justin Simmons | Backup | 2016 | 2-57 | T.J. Green | Starter | |
| 2016 | 4-136 | Devontae Booker | Backup | 2016 | 3-82 | Le’Raven Clark | Backup | |
| 2016 | 5-144 | Connor McGovern | Backup | 2016 | 4-116 | Hassan Ridgeway | Backup | |
| 2016 | 6-176 | Andy Janovich | Starter | 2016 | 4-125 | Antonio Morrison | Backup | |
| 2016 | 6-219 | Will Parks | Backup | 2016 | 5-155 | Joe Haeg | Starter | |
| 2016 | 7-228 | Riley Dixon | Starter | 2016 | 7-239 | Trevor Bates | Bust | |
| 2016 | 7-248 | Austin Blythe | Backup | |||||
Undrafted Rookie Free Agents
| Broncos | Colts | |||||
| 2012 | Aaron Brewer | Starter | 2012 | Griff Whalen | Backup | |
| 2012 | Steven Johnson | Backup | 2012 | Ty Nsekhe | Backup | |
| 2012 | Duke Ihenacho | Backup | 2013 | Erik Swoope | Backup | |
| 2013 | CJ Anderson | High Starter | 2013 | Josh McNary | Backup | |
| 2013 | Lerentee McCray | Backup | 2014 | Jontthan Harrison | Backup | |
| 2014 | Bennie Fowler | Backup | 2014 | Zach Kerr | Backup | |
| 2014 | Kapri Bibbs | Backup | 2014 | Zurlon Tipton | Backup | |
| 2014 | Juwan Thompson | Backup | 2014 | Loucheiz Purifoy | Backup | |
| 2014 | Shaquil Barrett | Backup | 2015 | Quan Bray | Backup | |
| 2014 | Isaiah Burse | Backup | 2015 | Curt Maggitt | Backup | |
| 2015 | Jordan Taylor | Backup | 2015 | Tyler Varga | Backup | |
| 2015 | Zaire Anderson | Backup | 2016 | Chester Rogers | Backup | |
| 2016 | Josh Ferguson | Backup | ||||
| 2016 | Andrew Williamson | Backup | ||||
Unrestricted Free Agents
| Broncos | Colts | |||||
| 2012 | Jacob Tamme | Starter | 2012 | Samson Satele | Starter | |
| 2012 | Joel Dreessen | Backup | 2012 | Mike McGlynn | Starter | |
| 2012 | Caleb Hanie | Backup | 2012 | Donnie Avery | Backup | |
| 2012 | Andre Caldwell | Backup | 2012 | Cory Redding | Starter | |
| 2012 | Justin Bannan | Starter | 2012 | Tom Zbikowski | Starter | |
| 2012 | Mike Adams | Starter | 2013 | Donald Thomas | Starter | |
| 2012 | Tracy Porter | Starter | 2013 | Ricky Jean-Francois | Starter | |
| 2013 | Wes Welker | High Starter | 2013 | Gosder Cherilus | Starter | |
| 2013 | Louis Vasquez | Pro Bowler | 2013 | Ahmad Bradshaw | Backup | |
| 2013 | Terrance Knighton | High Starter | 2013 | Aubrayo Franklin | Starter | |
| 2013 | Shaun Phillips | Starter | 2013 | Erik Walden | Starter | |
| 2013 | Quentin Jammer | Backup | 2013 | Greg Toler | Starter | |
| 2013 | Dominique Rodgers-Cromartie | High Starter | 2013 | LaRon Landry | Starter | |
| 2014 | Aqib Talib | Pro Bowler | 2014 | Hakeem Nicks | Backup | |
| 2014 | TJ Ward | Pro Bowler | 2014 | Arthur Jones | Starter | |
| 2014 | Emmanuel Sanders | Pro Bowler | 2014 | Mike Adams | Starter | |
| 2015 | Ryan Harris | Starter | 2014 | Colt Anderson | Backup | |
| 2015 | Owen Daniels | Starter | 2015 | Frank Gore | High Starter | |
| 2015 | Darian Stewart | High Starter | 2015 | Nate Irving | Backup | |
| 2016 | Russell Okung | Starter | 2015 | Dwight Lowery | Starter | |
| 2016 | Donald Stephenson | Starter | 2016 | Scott Tolzien | Backup | |
| 2016 | Jared Crick | Starter | 2016 | Robert Turbin | Backup | |
| 2016 | Dekoda Watson | Backup | 2016 | Jordan Todman | Backup | |
| 2016 | Patrick Robinson | Starter | ||||
Trades
| Broncos | Colts | |||||
| 2012 | Joe Mays | Starter | 2012 | Winston Justice | Starter | |
| 2012 | Chris Gronkowski | Backup | 2012 | Drew Stanton | Backup | |
| 2013 | John Moffitt | Backup | 2012 | Moise Fokou | Backup | |
| 2014 | Brandon McManus | High Starter | 2012 | Vontae Davis | Pro Bowler | |
| 2012 | Josh Gordy | Backup | ||||
| 2012 | DJ Johnson | Backup | ||||
| 2012 | Cassius Vaughn | Backup | ||||
| 2013 | Stanley Havili | Starter | ||||
| 2013 | David Reed | Backup | ||||
| 2013 | Kelvin Sheppard | Backup | ||||
| 2013 | Cam Johnson | Backup | ||||
| 2014 | Trent Richardson | LOL | ||||
| 2015 | Sio Moore | Starter | ||||
| 2015 | Billy Winn | Backup | ||||
Street Free Agents, Waiver Claims, Practice Squad Signings
| Broncos | Colts | |||||
| 2012 | Peyton Manning | MVP | 2012 | Dominique Jones | Backup | |
| 2012 | Ty Warren | Backup | 2012 | Kris Adams | Backup | |
| 2012 | Jim Leonhard | Backup | 2012 | AQ Shipley | Backup | |
| 2012 | Brandon Stokley | Starter | 2012 | Mewelde Moore | Backup | |
| 2012 | CJ Davis | Backup | 2012 | Jerrell Freeman | Starter | |
| 2012 | Keith Brooking | Starter | 2012 | Matt Overton | Starter | |
| 2012 | Trindon Holliday | Starter | 2012 | Darius Butler | Starter | |
| 2013 | Adrian Robinson | Backup | 2012 | Mario Harvey | Backup | |
| 2013 | Steve Vallos | Backup | 2012 | Justin Hickman | Backup | |
| 2013 | Paris Lenon | Backup | 2012 | Justin King | Backup | |
| 2013 | Brandon Marshall | Starter | 2013 | Da’Rick Rogers | Backup | |
| 2014 | DeMarcus Ware | Pro Bowler | 2013 | Andy Studebaker | Backup | |
| 2014 | Josh Bush | Backup | 2013 | Delano Howell | Backup | |
| 2014 | Will Montgomery | Backup | 2013 | Jack Doyle | Starter | |
| 2014 | Marvin Austin | Backup | 2013 | Sergio Brown | Backup | |
| 2014 | Jordan Norwood | Backup | 2013 | Darrius Heyward-Bey | Backup | |
| 2015 | Shelley Smith | Backup | 2013 | Matt Hasselbeck | Backup | |
| 2015 | Todd Davis | Starter | 2014 | Lance Louis | Starter | |
| 2015 | James Ferentz | Backup | 2014 | Henoc Muamba | Backup | |
| 2015 | Henry Mitchell | Backup | 2014 | Jalil Brown | Backup | |
| 2015 | James Casey | Backup | 2014 | Winston Guy | Backup | |
| 2015 | Vance Walker | Backup | 2014 | Xavier Nixon | Backup | |
| 2015 | Antonio Smith | Backup | 2014 | Dan Herron | Backup | |
| 2015 | Evan Mathis | Starter | 2014 | D’Qwell Jackson | Starter | |
| 2015 | Shiloh Keo | Backup | 2015 | Trent Cole | Starter | |
| 2016 | Casey Kreiter | Starter | 2015 | Earl Okine | Backup | |
| 2016 | Austin Davis | Backup | 2015 | Josh Thomas | Backup | |
| 2016 | John Phillips | Backup | 2015 | Shaun Prater | Backup | |
| 2016 | Darrion Weems | Backup | 2015 | Edwin Jackson | Backup | |
| 2016 | Billy Winn | Backup | 2015 | TY McGill | Backup | |
| 2015 | Kendall Langford | Starter | ||||
| 2015 | Andre Johnson | Backup | ||||
| 2015 | Todd Herremans | Backup | ||||
| 2016 | Akeem Ayers | Backup | ||||
| 2016 | Rashaan Melvin | Backup | ||||
| 2016 | Antonio Cromartie | Backup | ||||
| 2016 | Darryl Morris | Backup | ||||
| 2016 | Matthias Farley | Backup | ||||
| 2016 | Devin Street | Backup | ||||